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DNEL β
DNEL
Under REACH a level of exposure has to determined where exposure to the substance has no effect on humans, the so-called DNEL (derived no-effect-level). With exposure below the DNEL, no further protection measures are necessary. There are several target groups (workers, general population), exposure times (acute and long-term), effects (local and systemic effects) and exposure routes (inhalation, skin absorption, ingestion). Therefore there are a total of 15 different DNELs can be distinguished:
- Workers - Inhalation - Long term exposure - Systemic effect
- Workers - Inhalation - Long term exposure - Local effect
- Workers - Dermal - Long term exposure - Systemic effect
- Workers - Dermal - Long term exposure - Local effect
- Workers - Inhalation - Acute/short term exposure - Systemic effect
- Workers - Inhalation - Acute/short term exposure - Local effect
- Workers - Dermal - Acute/short term exposure - Local effect
- General population - Inhalation - Long term exposure - Systemic effect
- General population - Inhalation - Long term exposure - Local effect
- General population - Dermal - Long term exposure - Systemic effect
- General population - Dermal - Long term exposure - Local effect
- General population - Oral - Long term exposure - Systemic effect
- General population - Inhalation - Acute/short term exposure - Systemic effect
- General population - Inhalation - Acute/short term exposure - Local effect
- General population - Dermal - Acute/short term exposure - Local effect
If there no safe threshold can be derived, the manufacturer/supplier has to establish a so-called DMEL (Derived Minimal Effect Level).
In DOHSBase Compare only the available DNELs for the workers are displayed.
Changes in the presented DNEL/DMEL-values are not published clearly by ECHA. With the button "To Internet" on the right side of the field 'Basis' it is easy to access the search screen of the ECHA-database "Registered Substances". There you can easy find the current DMEL/DNEL-value (in the section "Toxicological information | Toxicological information.001"), or gather other information from this database.
Moreover, the link also appears also in the Comments field, as "deep link", directly to the substance information in the ECHA database "Registered Substances".
